Photocleavable linkers allow a high degree of chemoselectivity by controlling spatial, temporal, and concentration-dependent variables through the addition of light. Since the removal of the linker structure requires no chemical additives, this method is often referred to as a "traceless" process.
Site-specific chemical modification of antibody fragments Site-specific chemical modification of antibody fragments using traceless cleavable linkers. Gonçalo J L Bernardes 1,2,3, Martina Steiner 1, Isabelle Hartmann 1, Dario Neri 1 & Delivery and Release of Small-Molecule Probes in Here, we describe cleavable linkers designed for the traceless release of chemical cargo from MPPs following mitochondrial transit. The cleavage kinetics of a number of disulfides were investigated using a fluorescent reporter system in order to optimize linker stability for mitochondrial release. The stability of mono- and disubstituted Cleavable vs. Non-Cleavable Linkers in Antibody-Drug Dec 19, 2019
(PDF) Antibody-drug conjugates: recent advances in
Belyntic's Peptide Easy Clean (PEC) technology breaks barriers in peptide manufacturing. We designed a catch-and-release methodology based on novel traceless cleavable linker molecules (PEC-Linkers) and activated filter materials for the purification and modification of chemically synthesized peptides.
linker chemistry available for the traceless reversible coupling of polymers to proteins, with emphasis on methods for tuning the rate of de-PEGylation of the bio-conjugate. This review is limited to the conjugation of polymers to peptides/proteins, and will not discuss the conjugation
Creative Biolabs antibody cysteine modification platform has the unprecedented ability to produce antibodies introduced free cysteine without disrupting any antigen-targeting capacity, stability or homogeneity, which cannot be otherwise produced in any other platform. Advantages include quality, stability, purity, rapidly delivery as well as reduced production and development cost. NJ BIO — Introduction to Antibody-Drug Conjugates